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Timothy J Hoffman Selected Research

Bombesin Receptors (Bombesin Receptor)

2/2015Characterization and evaluation of DOTA-conjugated Bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy.
4/2014Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer.
6/2013Near-infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases.
12/2012Non-invasive microCT imaging characterization and in vivo targeting of BB2 receptor expression of a PC-3 bone metastasis model.
7/2012Positron-emission tomography (PET) imaging agents for diagnosis of human prostate cancer: agonist vs. antagonist ligands.
4/201264Cu-NO2A-RGD-Glu-6-Ahx-BBN(7-14)NH2: a heterodimeric targeting vector for positron emission tomography imaging of prostate cancer.
1/2010Evaluation of [99mTc-(CO)3-X-Y-Bombesin(7-14)NH2] conjugates for targeting gastrin-releasing peptide receptors overexpressed on breast carcinoma.
2/2009In vitro and in vivo analysis of [(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human breast cancer tumors.
10/2008Design, synthesis, and biological evaluation of an antagonist-bombesin analogue as targeting vector.
4/200899mTc(CO)3-DTMA bombesin conjugates having high affinity for the GRP receptor.
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Timothy J Hoffman Research Topics

Disease

37Neoplasms (Cancer)
02/2015 - 03/2002
11Prostatic Neoplasms (Prostate Cancer)
02/2015 - 02/2003
5Melanoma (Melanoma, Malignant)
07/2009 - 10/2002
5Colonic Neoplasms (Colon Cancer)
09/2006 - 03/2002
4Colorectal Neoplasms (Colorectal Cancer)
07/2010 - 07/2006
4Breast Neoplasms (Breast Cancer)
01/2010 - 07/2006
2Glioblastoma (Glioblastoma Multiforme)
02/2015 - 02/2014
2Neoplasm Metastasis (Metastasis)
06/2013 - 12/2012
2Carcinoma (Carcinomatosis)
01/2010 - 03/2006
2Pancreatic Neoplasms (Pancreatic Cancer)
05/2007 - 05/2003
1Lymphatic Metastasis
06/2013
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
10/2008
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
03/2008
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
04/2006
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2006

Drug/Important Bio-Agent (IBA)

23Peptides (Polypeptides)IBA
02/2015 - 10/2002
14Bombesin Receptors (Bombesin Receptor)IBA
02/2015 - 05/2003
11BombesinIBA
02/2015 - 05/2003
10RadiopharmaceuticalsIBA
02/2015 - 03/2002
91,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA
02/2015 - 03/2002
5LigandsIBA
02/2015 - 07/2007
5Biological ProductsIBA
04/2014 - 03/2002
5AcidsIBA
04/2014 - 05/2008
5Enterotoxins (Enterotoxin)IBA
07/2010 - 05/2006
5Gastrin-Releasing PeptideIBA
01/2010 - 05/2003
5alpha-MSHIBA
07/2009 - 10/2002
41,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA
04/2014 - 07/2007
4triazacyclononaneIBA
04/2014 - 02/2009
4Enterotoxin ReceptorsIBA
07/2010 - 03/2002
3Aminocaproic Acid (6 Aminocaproic Acid)FDA LinkGeneric
04/2014 - 10/2010
3Guanylate Cyclase (Guanylyl Cyclase)IBA
07/2010 - 05/2006
3Radioisotopes (Radionuclides)IBA
09/2007 - 01/2005
2IntegrinsIBA
02/2015 - 02/2014
2Copper-64IBA
04/2014 - 10/2010
2glycylhistidineIBA
04/2012 - 07/2003
2leucylmethionineIBA
04/2012 - 07/2003
2Chelating AgentsIBA
07/2010 - 03/2005
2uroguanylinIBA
10/2009 - 05/2006
2heat stable toxin (E coli)IBA
09/2006 - 05/2006
2AndrogensIBA
04/2006 - 05/2003
1GoldIBA
08/2014
1Biomarkers (Surrogate Marker)IBA
04/2014
1AntigensIBA
04/2014
15-aminovaleric acidIBA
04/2014
11- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA
04/2014
1arginyl-glycyl-aspartic acidIBA
04/2012
1Glutamic Acid (Glutamate)FDA Link
04/2012
14-Aminobenzoic Acid (4 Aminobenzoic Acid)IBA
10/2010
1beta-AlanineIBA
10/2010
1bombesin (7-14)IBA
01/2010
1Peptide Hormones (Polypeptide Hormones)IBA
10/2009
1RheniumIBA
07/2009
1(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)IBA
02/2009
1Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
03/2008
1(4,11- bis(carboxymethyl)- 1,4,8,11- tetraazabicyclo(6.6.2)hexadecane)copper(II)IBA
08/2007
1Fluorescent Dyes (Fluorescent Probes)IBA
05/2007
1Carrier Proteins (Binding Protein)IBA
07/2006
1Estrogen ReceptorsIBA
07/2006
1RNA (Ribonucleic Acid)IBA
07/2006
1guanylinIBA
07/2006
1VA 061 (VA061)IBA
04/2006
1Glucose (Dextrose)FDA LinkGeneric
04/2006
1Monoclonal AntibodiesIBA
03/2006
1Insulin (Novolin)FDA Link
01/2006
1MetalsIBA
03/2005
1Therapeutic UsesIBA
01/2005
1IndiumIBA
07/2004
12,3-diaminopropionic acidIBA
07/2003
1CarbonIBA
05/2003
1HydrocarbonsIBA
05/2003
1Amino AcidsFDA Link
10/2002
1Lysine (L-Lysine)FDA Link
10/2002
1DisulfidesIBA
03/2002

Therapy/Procedure

9Therapeutics
02/2015 - 10/2002
4Radiotherapy
02/2014 - 10/2002
2Intravenous Injections
02/2015 - 02/2014
2Drug Therapy (Chemotherapy)
09/2008 - 04/2006
1Radioimmunotherapy
03/2006
1Aftercare (After-Treatment)
01/2005